OUR WORK
Our research interests lie at the interface of developmental biology and neurobiology, where we combine molecular, cellular, and genetic approaches to understand the mechanisms of neurodevelopmental and neurodegenerative disorders. Have a look at some of my projects below.
PROTEOMIC CHARACTERIZATION OF THE HUMAN CEREBRAL CORTEX MICROENVIRONMENTS DURING DEVELOPMENT: EVOLUTIONARY AND CLINICAL RELEVANCE
Our proposed aims will shed light into how cell-extrinsic determinants present in distinct human brain microenvironments modulate generation, functional maturation and degeneration of human cortical neurons, and will improve our ability to develop targeted therapeutic approaches and design more effective clinical trials
DEFINING THE SPINAL CORD MATRISOME TO DESIGN MORE EFFECTIVE ALS MODELS AND TREATMENTS.
We aim to unbiasedly screen and validate extracellular matrix modifications in ALS patients’ spinal cords that could be critical for the motor neuron function and degeneration.
DEVELOPING NOVEL PLATFORMS FOR HUMANÂ STEM CELL-BASED CULTURES
We keep developing new in vitro platforms that aim to mimic the physiological microenvironments of the central nervous system for refining stem cell-based neuronal models. We believe that our tailorable and translatable platforms can generate new avenues of basic and translational stem cell-based research related to mechanisms of neurodegeneration and regeneration.